Colorectal cancer is the third most common cancer in the United States. Although screening has led to a decrease in incidence over the past 20 years, early-onset colorectal cancer has been rising.

Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...