The contractile responses of esophageal smooth muscle (SM) induced by platelet-activating factor (PAF) involve the activation of L-type voltage-dependent calcium channels (L-type VDCCs), ...
McGill University researchers have demonstrated that AMPA receptors (AMPARs), which mediate fast excitatory neurotransmission in the brain fundamental to learning and memory processes, exhibit varying ...
Researchers at Texas A&M Health and collaborators have developed engineered CRAC channel inhibitory binders that can ...
Memantine is an US Food and Drug Administration (FDA) approved drug that is thought to selectively inhibit NMDA-subtype of ionotropic glutamate receptors (NMDARs). NMDARs enable calcium influx into ...
Since the end of 2019, the COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection brings huge burden to the world that lacks efficient treatments and ...
Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...
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Why brain cells learn better: NMDA receptor maps may explain memory-linked calcium flow
The human brain constantly adapts in response to experiences, forming new connections between neurons and reorganizing existing ones. The brain's ability to adapt in response to experiences is known ...
A research group has uncovered important details about how platelet-activating factor (PAF)—a powerful molecule involved in inflammation and allergic reactions—triggers contractions in the smooth ...
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