As we age, our cells accumulate mutations. The vast majority of these mutations are inconsequential because they do not alter cell fitness. However, a small proportion of these mutations, termed ...

In simple terms: a mutation is a stable change in genetic sequence that can be copied when cells or viruses replicate. Most mutations have no detectable effect, some contribute to disease, and a small ...

The mutation rate of a specific position in the human genome depends on the sequence context surrounding it. Modeling the mutation rate by estimating a rate for each possible k-mer, however, only ...