Determining true HER2 status in breast cancers with polysomy using alternative chromosome 17 reference genes: Implications for trastuzumab therapy. Background: Systemic chemo- and chemoradiation ...

DNA methylation microarrays can be employed to interrogate cell-type composition in complex tissues. Here, we expand reference-based deconvolution of blood DNA methylation to include 12 leukocyte ...

The study protocol was approved by the Ethics Committee of the University of Fukui, Japan (Assurance no. 20200028), Yamaguchi University School of Medicine, Japan (Assurance no. 2020–202), and Sugita ...

While microarray technology is broadening its applications in genomics and proteomics, the technique remains a vibrant contributor in the area of gene expression. Much of the overall developmental ...

Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states. But the molecular mechanisms that ...

Definition: A microarray is a small, flat substrate carrying an ordered grid of microscopic probe features, each containing a known biological molecule, that is used to measure many molecular targets ...

DNA methylation is an epigenetic modification characterized by the addition of a methyl group to a DNA molecule. As DNA methylation is implicated in both normal biological processes, such as ...

In the central nervous system, microglial cells play critical roles in development, aging, brain homeostasis, and pathology. Recent studies have shown variation in the gene-expression profile and ...

Precision medicine experts take into account several factors when developing appropriate treatments for diseases, including population risk or incidence, the underlying genetic cause and potential ...

DNA Methylation: Timekeeper of Biological Age from thescientistllc on Vimeo. Cellular senescence, telomere shortening, and changes in gene expression have been well documented to contribute to the ...

Different applications have different requirements, so researchers need to carefully weigh their options when deciding whether to switch to a new platform. [© WavebreakmediaMicro – Fotolia.com] With ...

Philadelphia, December 28, 2021 – In the central nervous system, microglial cells play critical roles in development, aging, brain homeostasis, and pathology. Recent studies have shown variation in ...