A research team has successfully identified a novel DNA damage repair pathway in human cells. This study is the first to discover that proteins present in the nuclear membrane of cells directly ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This discovery ...

A cancer drug target already being investigated in clinical trials turns out to be doing something even more consequential ...

A research team from the University of California, Irvine has revealed a previously unknown mechanism that triggers an inflammatory immune response in cells when their DNA is damaged. This discovery ...

Daegu Gyeongbuk Institute of Science and Technology (DGIST; President Kunwoo Lee) announced that a research team led by Professor Younghoon Kee from the Department of New Biology has successfully ...

Clinical and Preclinical Activity of EGFR Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancer Harboring BRAF Class 3 Mutations This was a phase II multicenter trial in which refractory solid ...

Extrachromosomal DNA (ecDNA) is a unique form of circular DNA that exists outside of normal chromosomes. Found exclusively in tumor cells, it often carries cancer-promoting genes (oncogenes) and is ...

Researchers have identified a specific class of brain neurons that dies during multiple sclerosis because inflammation ...

DPY30 was identified as a promoter of cancer cell proliferation and tumor survival. Targeting this protein may enhance the ...